C-11 Pro2
Simplify Routine Production
The C-11 Pro2 is our next generation synthesizer designed from years of R&D to simplify the routine production of 11C radiotracers. 11CO2 is trapped at room temp and rapidly released using a volume optimized molecular sieve column. Capable of producing either methyl-iodide or methyltriflate via our highly optimised “wet” chemistry method, with labelling performed by traditional reaction vial or room temperature loop labelling*, the C-11 Pro2 also comes with built-in HPLC purification and disposable cassette S.P.E. product reformulation. Coupled with a fully automated wash-up system, the C-11 Pro2 is the complete solution for all your 11C production requirements in the one device.
C-11 PRO2 TECHNICAL SPECIFICATIONS
HARDWARE
11CO2 Trapping
Reactors
AgOTf column
Labelling reaction
Process Valves
HPLC Valves
HPLC pump
HPLC UV detector
Product reformulation
Automation
Other features
• Solid phase room temperature trapping of 11CO2 onto molecular sieve
• Rapid heating to 250°C (11CO2 releases at 180°C)
• Compressed air cooling
• Dual 1.1mL disposable tapered bottom glass reactors
• Rapid heating to 250°C and compressed air cooling
• Production of methyl-iodide in reactor 1 via the “wet chemistry” method
• Reactor 2 used for labelling reactions with syringe driven HPLC loop loading
• Built-in with rapid heating up to 250°C for online conversion of methyl-iodide into methyl-triflate
• Either by traditional reaction vial (Reactor 2) or
• Room temperature loop labelling*
• 9 Electric multi-position valves
• 13.6 bar (200psi), 1.32 mm orifice, 20uL internal volume
• Built-in automatic injector
• Manual injector (for precursor loading for loop labelling reactions with 2mL stainless steel loop
• Knauer 50 mL/min pump
• Optional quaternary L.P.G. & quad channel degasser
• Knauer detector with remote fibre optic flow cell
• Variable wavelength (190-750 nm)
• Disposable sterile kit with reverse phase S.P.E. cartridge reformulation
• Non-proprietary commercially available components
• Industrial PLC with Ethernet communications
• All compressed air used for reactor or column cooling is contained and can be exhausted outside of the hotcell to avoid hotcell contamination or pressurization
SENSORS
Radioactivity
Pressure
Flow
Temperature
• 6-collimated linear CsI(TI) crystal PIN diode radioactivity detectors
• Pressure sensor for inert gas pressure monitoring
• Mass Flow Controller for precise inert gas metering
• 4 thermocouple sensors for reactor and column heaters
SOFTWARE
Graphical interface
Synthesis recipes
HPLC control
• Easy to use open platform operator interface, with sensor trends, historical data logging & analysis, synthesis reports, multi-level user access
• Easily generated using unique Click-&-Save graphical technology and stored as Excel® step lists
• HPLC pump flow, eluent composition and gradients controlled directly from C-11 Pro2’s graphical interface (with optional LPG module)
UTILITIES &
DIMENSIONS
Compressed Air
Inert Gas
Case
Dimensions
• 6-8 bar (87-116 psi), 6 mm O.D. connection
• Helium, Nitrogen or Argon, 2-8 bar (29-116 psi)
• Compact 316 stainless steel
• Easy installation
• 510 mm x 415 mm x 340 mm (WxHxD)