C-11 Pro2

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Simplify Routine Production

The C-11 Pro2 is our next generation synthesizer designed from years of R&D to simplify the routine production of 11C radiotracers. 11CO2 is trapped at room temp and rapidly released using a volume optimized molecular sieve column. Capable of producing either methyl-iodide or methyltriflate via our highly optimised “wet” chemistry method, with labelling performed by traditional reaction vial or room temperature loop labelling*, the C-11 Pro2 also comes with built-in HPLC purification and disposable cassette S.P.E. product reformulation. Coupled with a fully automated wash-up system, the C-11 Pro2 is the complete solution for all your 11C production requirements in the one device.

C-11 PRO2 TECHNICAL SPECIFICATIONS

HARDWARE

11CO2 Trapping

 

 

 

Reactors

 

 

 

 

AgOTf column

 

 

Labelling reaction

 

 

Process Valves

 

 

HPLC Valves

 

 

 

HPLC pump

 

 

HPLC UV detector

 

 

Product reformulation

 

 

Automation

 

Other features

 

• Solid phase room temperature trapping of 11CO2 onto molecular sieve

• Rapid heating to 250°C (11CO2 releases at 180°C)

• Compressed air cooling

 

• Dual 1.1mL disposable tapered bottom glass reactors

• Rapid heating to 250°C and compressed air cooling

• Production of methyl-iodide in reactor 1 via the “wet chemistry” method

• Reactor 2 used for labelling reactions with syringe driven HPLC loop loading

 

• Built-in with rapid heating up to 250°C for online conversion of methyl-iodide into methyl-triflate

 

• Either by traditional reaction vial (Reactor 2) or

• Room temperature loop labelling*

 

• 9 Electric multi-position valves

• 13.6 bar (200psi), 1.32 mm orifice, 20uL internal volume

 

• Built-in automatic injector

• Manual injector (for precursor loading for loop labelling reactions with 2mL stainless steel loop

 

• Knauer 50 mL/min pump

• Optional quaternary L.P.G. & quad channel degasser

 

• Knauer detector with remote fibre optic flow cell

• Variable wavelength (190-750 nm)

 

• Disposable sterile kit with reverse phase S.P.E. cartridge reformulation

• Non-proprietary commercially available components

 

• Industrial PLC with Ethernet communications

 

• All compressed air used for reactor or column cooling is contained and can be exhausted outside of the hotcell to avoid hotcell contamination or pressurization

SENSORS

Radioactivity

 

Pressure

 

Flow

 

Temperature

 

 

• 6-collimated linear CsI(TI) crystal PIN diode radioactivity detectors

 

• Pressure sensor for inert gas pressure monitoring

 

• Mass Flow Controller for precise inert gas metering

 

• 4 thermocouple sensors for reactor and column heaters

SOFTWARE

Graphical interface

 

 

Synthesis recipes

 

 

HPLC control

 

 

• Easy to use open platform operator interface, with sensor trends, historical data logging & analysis, synthesis reports, multi-level user access

 

• Easily generated using unique Click-&-Save graphical technology and stored as Excel® step lists

 

• HPLC pump flow, eluent composition and gradients controlled directly from C-11 Pro2’s graphical interface (with optional LPG module)

UTILITIES &

DIMENSIONS

Compressed Air

 

Inert Gas

 

Case

 

 

Dimensions

 

 

• 6-8 bar (87-116 psi), 6 mm O.D. connection

 

• Helium, Nitrogen or Argon, 2-8 bar (29-116 psi)

 

• Compact 316 stainless steel

• Easy installation

 

• 510 mm x 415 mm x 340 mm (WxHxD)